Coaxial 3D printing of hierarchical structured hydrogel scaffolds for repair of spinal cord injury
In vivo evaluation of bone scaffold fabricated by 3D bioprinting method by researchers of OmidAfrinan company
Fabrication of 3D printed hybrid scaffolds carrying dental pulp stem cells
Bioprinting Bone Constructs During Surgery
The beating of the first bioprinted human heart created from stem cells
۳D Bioprinted Multicellular Vascular Models
۳D Printed Punctal Plugs for Controlled Ocular Drug Delivery
۳D Bioprinted Multicellular Vascular Models
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A team of researchers at Texas A&M University (TX, USA) have developed and grown a bioprinted blood vessel able to mimic specific states of health and disease, allowing for the possibility of precision cardiovascular drug advancements. reference: Gold KA,...
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Recently researchers at the National University of Singapore, have been used chitosan methacrylate and PCL as base hydrogel and backing layer respectively to fabricate customizable wound dressings via 3D printing. Synthesized chitosan methacrylate is evaluated to be printable,...
۳D bio printed spheroid with lobule-like constructs and liver functions
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Recently, Korean researchers presents a method for producing hepatic-lobule-like microtissue spheroids using a bioprinting system and microfluidic emulsification system. A noteworthy point in this study is the use of a precursor cartridge to create a specific pattern in how...
Four-dimensional bioprinting
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Four-dimensional (4D) bioprinting, in which the concept of time is integrated with three-dimensional (3D) bioprinting as the fourth dimension, with the goal of constructing complex, functional structures. 4D bioprinting can be used to fabricate dynamic 3D-patterned biological architectures that...
Four-axis 3D printing for the fabrication of tubular scaffolds with tailorable mechanical properties
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Researchers developed a four axis extrusion-based additive manufacturing system based on fused deposition modeling (FDM) to create tubular hollow scaffolds. With this technique systematic changes in design can be made to alter the mechanical properties for the targeted tissue...
Genetically-programmed, cell-laden & mechanically strong 3D bioprinted scaffolds for bone repair
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Combined delivery of stem cells with the controlled release of osteogenic factors, within a mechanically-strong biomaterial combined during manufacturing would replace injectable defect fillers (cements) and allow personalized implants to be rapidly prototyped by 3D bioprinting. To this end,...
An in-vitro liver model using 3D bioprinting core–shell structure of hepatocytes and fibroblasts
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With the aim of understanding cellular interactions of hepatocytes in their physiological microenvironment and to generate an artificial 3D in vitro model of liver, a co-culture system using 3D extrusion bioprinting was developed. In this method, bio-ink based on...
The first 3D-printable ‘bottlebrush’ elastomer
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Researchers have developed the first 3D-printable ‘bottlebrush’ elastomer. The new material results in printed objects that have unusual softness, elasticity and mechanical properties that closely resemble those of human tissue. Unique molecular structure of bottlebrush elastomers facilitate bioprinting in...
Ceramic-based ink to 3D-print bone parts with living cells
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A team of researchers at UNSW (Sydney, Australia) develops a novel, ceramic-based ink to print bone-like structures that harden within minutes of being placed in water. REFERENCE: Romanazzo S, Molley TG, Nemec S et al. Synthetic bone-like structures...
Bioprinted, personalized scaffolds for ankle joint tissue regeneration in development.
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The TRIANKLE consortium made up of 12 European organizations has come together to develop bioprinted, personalized scaffolds for ankle joint tissue regeneration. reference: https://www.3dmednet.com/ https://www.cellink.com/
۳D bioprinting of anisotropic engineered tissue constructs with ultrasonically induced cell patterning
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US researchers have developed a new bioprinting technique that uses ultrasonic standing bulk acoustic waves (SBAW) to organize cells into controllable anisotropic patterns within viscous bioinks while maintaining high cell viability. This work represents a step forward in advancing...
Fabrication of Three-Dimensional Composite Scaffold for Simultaneous Alveolar Bone Regeneration in Dental Implant Installation
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Korean researchers have designed a 3D printed composite scaffold that can be combined simultaneously with bone grafts and fixtures to minimize the cost and duration of dental implant surgery. Further, by using 3D printing technology in making this implant,...
Evaluation of the effects of cell-dispensing using an inkjet-based bioprinter on cell integrity
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Japanese researchers have developed a stress-free and media-direct-dispensing inkjet bioprinter that exhibited cell-friendly dispensing performance, which was similar to the manual dispensing operation, based not only on cell viability but also on gene expression levels. reference: https://www.nature.com/articles/s41598-020-64193-z Yumoto M,...
Bioprinting of cartilage tissue using a 3D bioprinter in the treatment of knee joint injuries
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With the help of bio-3D printing technology, scientists have succeeded in printing 3D cartilage tissue that can easily help those suffering from osteoarthritis or other knee injuries. reference: Costa JB, Park J, Jorgensen AM, Silva-Correia J, Reis RL, Oliveira...
Vascularized cell-laden 3D bioprinted wound dressings for regenerative medicine applications
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Using three-dimensional printed structures with vascular networks is considered as a novel cell-based therapy for regenerative medicine applications. A team of researchers at the University of Otago (New Zealand) reports a promising strategy using core shell extrusion 3D bioprinting...
۳D Printing of Bone Grafts for Cleft Alveolar Osteoplasty
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One of the most common hereditary craniofacial anomalies in humans are cleft lip and cleft alveolar bone with or without cleft palate. German researchers developed a novel therapy concept based on 3D printing of biodegradable calcium phosphate-based materials allowing...
Enhancement of 3D cell printing by using silk nanofibers
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In a study recently published in Materials Today Bio, researchers from Osaka University have used silk nanofibers obtained by mechanical disintegration to enhance the printing process without damaging the cells or cell assemblies. reference: https://www.3dmednet.com/silk-fibers-provide-integrity-and-prevent-cell-damage-in-3d-printed-biological-constructs/ Sakai S, Yoshii A,...
Bioprinting and computer modeling facilitates study of cancer spread in blood vessels.
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A team of scientists from the Lawrence Livermore National Laboratory (CA, USA) has used bioprinted, living brain vasculature models in tandem with computer modeling simulations to provide insights on why cancer cells metastasize in certain areas of the vasculature....
Novel bioink for 4D bioprinting tissue-mimicking materials
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A team of researchers from Linköping University (Sweden) has developed a modular and 3D printable hyaluronan-based hydrogels to keep cells alive throughout the printing process. reference Aronsson, C., Jury, M., Naeimipour, S., Boroojeni, F. R., Christoffersson, J., Lifwergren, P.,...
۳D-printed capsule could collect bacteria from throughout the gastrointestinal tract
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A novel 3D-printed capsule, developed by a team at Purdue University (IL, USA), could allow for the collection of bacteria samples from throughout the gastrointestinal tract, improving on conventional sampling methods that may exclude areas for bacteria collection outside...
۳D-printed patches for long term release of drugs to treat myocardial infarction
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Up to now, many methods have been presented to treat cardiovascular diseases as the first cause of human death worldwide. In a recent study by Finish scientists, multifunctional patches presenting suitable biocompatibility, electrical conductivity, and mechanical strength have been...
Noninvasive in vivo 3D bioprinting
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Despite the extensive advances in 3D bioprinting, its in vivo application has been limited to the cases with exposed traumas (such as burn wounds) or requires a surgical operation. In a recent study by Chinese scientists, the noninvasive in...
Oxygen Generating Bioinks: An Approach Providing Oxygen to Cells Encapsulated in Non Vasculirized Grafts
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Of the main challenges against the translation of tissue-engineered grafts is the lack of enough oxygen in thick tissues known as hypoxia. Interestingly, there is a category of materials that generate oxygen. In a recent study, a bioink of...
Intravital three dimensional bioprinting
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A group of researchers from the University College London and the University of Padua (Italy) unveiled a minimally invasive 3D bioprinting technique that can be used for the fabrication of 3D constructs across and within tissues. This study results,...