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تصویر: ۳D Bioprinted Multicellular Vascular Models

۳D Bioprinted Multicellular Vascular Models

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A team of researchers at Texas A&M University (TX, USA) have developed and grown a bioprinted blood vessel able to mimic specific states of health and disease, allowing for the possibility of precision cardiovascular drug advancements. reference: Gold KA,...

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  Recently researchers at the National University of Singapore, have been used chitosan methacrylate and PCL as base hydrogel and backing layer respectively to fabricate customizable wound dressings via 3D printing. Synthesized chitosan methacrylate is evaluated to be printable,...

تصویر: ۳D bio printed spheroid with lobule-like constructs and liver functions

۳D bio printed spheroid with lobule-like constructs and liver functions

Recently, Korean researchers presents a method for producing hepatic-lobule-like microtissue spheroids using a bioprinting system and microfluidic emulsification system.  A noteworthy point in this study is the use of a precursor cartridge to create a specific pattern in how...

تصویر: ۳d bioprining skin tissues model using primary cells

۳d bioprining skin tissues model using primary cells

In a study by Cellink researchers, a full thickness skin tissue model was bioprinted. In this study, the dermis was bioprinted using primary dermal fibroblasts embedded in GelMA based bioink, and the epidermis, containing a high concentration of keratinocytes...

تصویر: Four-axis 3D printing for the fabrication of tubular scaffolds with tailorable mechanical properties

Four-axis 3D printing for the fabrication of tubular scaffolds with tailorable mechanical properties

Researchers developed a four axis extrusion-based additive manufacturing system based on fused deposition modeling (FDM) to create tubular hollow scaffolds. With this technique systematic changes in design can be made to alter the mechanical properties for the targeted tissue...

تصویر: Genetically-programmed, cell-laden & mechanically strong 3D bioprinted scaffolds for bone repair

Genetically-programmed, cell-laden & mechanically strong 3D bioprinted scaffolds for bone repair

Combined delivery of stem cells with the controlled release of osteogenic factors, within a mechanically-strong biomaterial combined during manufacturing would replace injectable defect fillers (cements) and allow personalized implants to be rapidly prototyped by 3D bioprinting. To this end,...

تصویر: An in-vitro liver model using 3D bioprinting core–shell structure of hepatocytes and fibroblasts

An in-vitro liver model using 3D bioprinting core–shell structure of hepatocytes and fibroblasts

With the aim of understanding cellular interactions of hepatocytes in their physiological microenvironment and to generate an artificial 3D in vitro model of liver, a co-culture system using 3D extrusion bioprinting was developed. In this method, bio-ink based on...

تصویر: The first 3D-printable ‘bottlebrush’ elastomer

The first 3D-printable ‘bottlebrush’ elastomer

Researchers have developed the first 3D-printable ‘bottlebrush’ elastomer. The new material results in printed objects that have unusual softness, elasticity and mechanical properties that closely resemble those of human tissue. Unique molecular structure of bottlebrush elastomers facilitate bioprinting in...

تصویر: Bioprinted, personalized scaffolds for ankle joint tissue regeneration in development.

Bioprinted, personalized scaffolds for ankle joint tissue regeneration in development.

The TRIANKLE consortium made up of 12 European organizations has come together to develop bioprinted, personalized scaffolds for ankle joint tissue regeneration.   reference: https://www.3dmednet.com/ https://www.cellink.com/

تصویر: Nucleotide lipid-based hydrogel as a new route to produce crosslinker-free scaffolds

Nucleotide lipid-based hydrogel as a new route to produce crosslinker-free scaffolds

Despite recent advances in tissue engineering and biofabrication, progress has been limited to the development of bioinks based on polymers.  Scientist show that a nucleotide lipid-based hydrogel resulting from the self-assembly of nucleotide lipids can be used as a...

تصویر: Fabrication of Three-Dimensional Composite Scaffold for Simultaneous Alveolar Bone Regeneration in Dental Implant Installation

Fabrication of Three-Dimensional Composite Scaffold for Simultaneous Alveolar Bone Regeneration in Dental Implant Installation

Korean researchers have designed a 3D printed composite scaffold that can be combined simultaneously with bone grafts and fixtures to minimize the cost and duration of dental implant surgery. Further, by using 3D printing technology in making this implant,...

تصویر: Mini-kidneys bioprinted for toxicology research and treatment developments

Mini-kidneys bioprinted for toxicology research and treatment developments

A team of Australian researchers apply extrusion-based three-dimensional cellular bioprinting to deliver rapid and high-throughput generation of kidney organoids with highly reproducible cell number and viability. Automated extrusion-based bioprinting for kidney organoid production delivers improvements in throughput, quality control,...

تصویر: Evaluation of the effects of cell-dispensing using an inkjet-based bioprinter on cell integrity

Evaluation of the effects of cell-dispensing using an inkjet-based bioprinter on cell integrity

Japanese researchers have developed a stress-free and media-direct-dispensing inkjet bioprinter that exhibited cell-friendly dispensing performance, which was similar to the manual dispensing operation, based not only on cell viability but also on gene expression levels. reference: https://www.nature.com/articles/s41598-020-64193-z Yumoto M,...

تصویر: Vascularized cell-laden 3D bioprinted wound dressings for regenerative medicine applications

Vascularized cell-laden 3D bioprinted wound dressings for regenerative medicine applications

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Using three-dimensional printed structures with vascular networks is considered as a novel cell-based therapy for regenerative medicine applications. A team of researchers at the University of Otago (New Zealand) reports a promising strategy using core shell extrusion 3D bioprinting...

تصویر: Enhancement of 3D cell printing by using silk nanofibers

Enhancement of 3D cell printing by using silk nanofibers

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In a study recently published in Materials Today Bio, researchers from Osaka University have used silk nanofibers obtained by mechanical disintegration to enhance the printing process without damaging the cells or cell assemblies. reference: https://www.3dmednet.com/silk-fibers-provide-integrity-and-prevent-cell-damage-in-3d-printed-biological-constructs/ Sakai S, Yoshii A,...

تصویر: Bioprinting and computer modeling facilitates study of cancer spread in blood vessels.

Bioprinting and computer modeling facilitates study of cancer spread in blood vessels.

A team of scientists from the Lawrence Livermore National Laboratory (CA, USA) has used bioprinted, living brain vasculature models in tandem with computer modeling simulations to provide insights on why cancer cells metastasize in certain areas of the vasculature....

تصویر: ۳D-printed capsule could collect bacteria from throughout the gastrointestinal tract

۳D-printed capsule could collect bacteria from throughout the gastrointestinal tract

A novel 3D-printed capsule, developed by a team at Purdue University (IL, USA), could allow for the collection of bacteria samples from throughout the gastrointestinal tract, improving on conventional sampling methods that may exclude areas for bacteria collection outside...

تصویر: Novel bioprinting platform supports bone regeneration

Novel bioprinting platform supports bone regeneration

A collaborative team from the SFI Research Centre for Advanced Materials and Bioengineering Research (AMBER; Dublin, Republic of Ireland) and the Trinity Centre for Biomedical Engineering at Trinity College Dublin (Republic of Ireland) has developed a novel bioprinting platform...

تصویر: Bioprinting of Beating Heart Tissue with human induced pluripotent stem cells (hiPSCs)

Bioprinting of Beating Heart Tissue with human induced pluripotent stem cells (hiPSCs)

Researchers at the University of Minnesota (UMN) by developing a new bio-ink were able to bioprint a centimeter-scale heart pump with real human cells. The extracellular matrix (ECM)-based bioink used in this study enabled stem cells to proliferate before differentiation, allowing the team...

تصویر: Anatomical-scale functional bone tissues are developed by 3D bioprinting of nanoengineered bioinks

Anatomical-scale functional bone tissues are developed by 3D bioprinting of nanoengineered bioinks

Designing patient-specific bone grafts by 3D-bioprinting technology has gathered a great deal of attention from researchers and clinicians. In this vein, a research group at Texas A&M University has developed an advanced bioink known as Nanoengineered Ionic–Covalent Entanglement (NICE)...

تصویر: The First 3D Bioprinting Experiment In Space Is Achieved

The First 3D Bioprinting Experiment In Space Is Achieved

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In a collaboration between the Geneva Foundation (Geneva), the Uniformed Services University of the Health Sciences (USU), commercial space company TechShot, Inc, and 3D printer manufacturer nScrypt, Inc, the first bioprinting project in space about the engineering of the...

تصویر: ۳D bioprinting of constructs made of hydrogels and thermoplastic polymers for articular cartilage engineering

۳D bioprinting of constructs made of hydrogels and thermoplastic polymers for articular cartilage engineering

In a national collaboration of Spain scientists, a new bio-ink made of alginate and hyaluronic acid was developed for articular cartilage engineering. To provide the mechanical properties required in cartilage tissue, Polylactic acid was co-printed with the cell-encapsulated hydrogel....

تصویر: ۳D-Printing Responds to Covid-19 Outbreak: A Review on Simple and Feasible Ideas

۳D-Printing Responds to Covid-19 Outbreak: A Review on Simple and Feasible Ideas

With the outbreak of the coronavirus, the daily activities have been significantly disrupted. Therefore, the efforts of many research institutes in the world are focused on combating the spread of the virus. In this session of 3D Bio Club,...

تصویر: Priming mesenchymal stem cells in vivo: A game-changer to treat myocardial infarction induced hearts

Priming mesenchymal stem cells in vivo: A game-changer to treat myocardial infarction induced hearts

Despite the great potential of mesenchymal stem cells in various regeneration therapies, their application to treat myocardial infarction (MI)–induced hearts is limited. In  recent research by an international joint research team of POSTECH, Seoul St. Mary’s Hospital, and City...